Is a gene‐centric human proteome project the best way for proteomics to serve biology?
Identifieur interne : 007254 ( Main/Exploration ); précédent : 007253; suivant : 007255Is a gene‐centric human proteome project the best way for proteomics to serve biology?
Auteurs : Thierry Rabilloud [France] ; Denis Hochstrasser [Suisse] ; Richard J. Simpson [Australie]Source :
- PROTEOMICS [ 1615-9853 ] ; 2010-09.
Descripteurs français
English descriptors
- KwdEn :
- Alternate splice variants, Antibody, Antibody format, Association studies, Cell biol, Clinical proteomics, Complex sample, Comprehensiveness, Dynamic range, Gene, Human, Human genome project, Human proteome, Human proteome project, Mammalian cells, Mass spectrometry, Multidimensional protein technology, Multiple reaction monitoring, Other omics, Other words, Peptide, Protein, Protein complexes, Protein concentrations, Protein degradation, Protein level, Proteome, Proteome project, Proteomics, Proteomics community, Proteotypic, Proteotypic peptide, Proteotypic peptides, Quantitative proteomics, Single reaction monitoring, Success rate, Verlag gmbh, Weinheim proteomics, Yeast, Yeast proteome.
- Teeft :
- Alternate splice variants, Antibody format, Association studies, Cell biol, Clinical proteomics, Complex sample, Comprehensiveness, Dynamic range, Human genome project, Human proteome, Human proteome project, Mammalian cells, Mass spectrometry, Multidimensional protein technology, Multiple reaction monitoring, Other omics, Other words, Peptide, Protein, Protein complexes, Protein concentrations, Protein degradation, Protein level, Proteome, Proteome project, Proteomics, Proteomics community, Proteotypic, Proteotypic peptide, Proteotypic peptides, Quantitative proteomics, Single reaction monitoring, Success rate, Verlag gmbh, Weinheim proteomics, Yeast, Yeast proteome.
Abstract
With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In “proteomics speak”, the debate revolves around the central question as to whether a gene‐centric or a protein‐centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large‐scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.
Url:
DOI: 10.1002/pmic.201000220
Affiliations:
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However, there is still debate as to how it should be designed and what it should encompass. In “proteomics speak”, the debate revolves around the central question as to whether a gene‐centric or a protein‐centric proteomics approach is the most appropriate way forward. 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Simpson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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